Page 69 - 32
P. 69
نتیجه‌گیری
با توجه به نتایج مطالعه حاضر هر دو دارو در کاهش فرکانس و شدت تشنج موثر بودند و استفاده از هر دو دارو را م يتوان برای بیماران
هر چند که عوارض داروی لووتیراستام نسبت به داروی والپروات کمتر بود اما برای توصیه آن به جای والپروات باید در حجم.توصیه نمود
u .نمونه بالاتر و با زمان پیگیری بیشتر مطالعه انجام پذیرد
منابع و مأخذ
1- Rowland LP, Pedley TA. Merritt's Neurology. 12th ed .Philadelphi, PA 19106 USA: Lippincott Williams &
Wilkins; 2010.p.927-948.
2- Ropper AH, Samuels MA, Klein JP. Adams & Victor’s Principles of Neurology. 10th ed. USA: McGraw-Hill
Education; 2014.p. 318-356.
3- Nieto-Barrera M, Brozmanova M, Capovilla G, Christ W. A comparison of monotherapy with lamotrigine or
carbamazepine in patients with newly diagnosed partial epilepsy. Epilepsy Res 2001; 46:145–155.
4- Costa J, Fareleira F, Ascencao R, Borges M, Sampaio C, Vaz-Carneiro A. Clinical comparability of the new
antiepileptic drugs in refractory partial epilepsy: A systematic review and meta-analysis. Epilepsia 2011; 52:1280-
1291.
5- Costa J, Fareleira F, Ascencao R, et al. Clinical comparability of the new antiepileptic drugs in refractory partial
epilepsy: A systematic review and meta-analysis. Epilepsia. Jul 2011;52(7):1280-91.
6- Birbeck GL, French JA, Perucca E, Simpson DM, Fraimow H, George JM, et al. Evidence-based guideline:
Antiepileptic drug selection for people with HIV/AIDS: Report of the Quality Standards Subcommittee of the
American Academy of Neurology and the Ad Hoc Task Force of the Commission on Therapeutic Strategies of the
International League Against Epilepsy. Neurology 2012; 78:139-145.
7- Tanaka S, Tanaka T. Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy.
Epileptic Disord 2013; 15:132-141.
8- Noyer M, Gillard M, Matagne A, Hénichart JP, Wülfert E. The novel antiepileptic drug levetiracetam (ucb L059)
appears to act via a specific binding site in CNS membranes. Eur J Pharmacol 1995; 286:137-146.
9- Wu Xy, Hong Z, Wu X, Wu LW, Wang XF, Zhou D, et al. Multicenter double-blind, randomized, placebo-
controlled trial of levetiracetam as add-on therapy in Chinese patients with refractory partial-onset seizures.
Epilepsia 2009; 50:971.
10- Cataldi M, Lariccia V, Secondo A, di Renzo G, Annunziato L. The antiepileptic drug levetiracetam decreases
the inositol 1,4,5-trisphosphate-dependent [Ca2+]I increase induced by ATP and bradykinin in PC12 cells. J
Pharmacol Exp Ther 2005; 313:720-730.
11- Tsai JJ, Yen DJ, Hsih MS, Chen SS, Hiersemenzel R, Edrich P, et al. Efficacy and safety of levetiracetam
(up to 2000 mg/day) in Taiwanese patients with refractory partial seizures: a multicenter, randomized, double-blind,
placebo-controlled study. Epilepsia 2006; 47:72-81.
67
